Endocrine Abstracts

Purpose: To assess the effect of radiation therapy (RT) in patients with acromegaly, depending on the age of the patients and the activity of the formation.Materials and methods: The object of the study was 50 patients (36 women and 14 men) with acromegaly who received gamma-therapy in a total dose of 45-60 Gr. The age of patients ranged from 29 to 77 years. By age, the patients were divided into 3 groups: 1st age group-29–44years old-23patients (46...

The purpose of the study: To examine the incidence of neuroendocrine complications after RT of pituitary somatotropinomas.Materials and methods: Thirty patients surveyed after receiving radiation therapy (RT) at a dose of 45 g in 25 fractions a day. Of these, 21 (70%) females, 9 (30%) men. The age of patients ranged from 36–71 years. 37% of them had pituitary macroadenoma with para-, supra-, infrasellar growth. Duration of illness was on average 15 ...

Purpose of the study: To determine the gender differences in growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in patients with somatotropic pituitary adenomas after radiation therapy (RT).Materials and research methods: The object of the study is 94 patients with acromegaly receiving RT in a total dose of 45–50 gray. Of these, 26 (27.7%) are men and 68 (72.3%) are women. The peak manifestation of acromegaly in the total sample was in th...

The aim of the study was to study the incidence of osteo-articular complications in patients with acromegaly in the Ferghana Valley.Materials and methods: 129 patients with acromegaly in the Ferghana Valley who were included in the national register of acromegaly were examined. Of these, men – 46 (35.7%), women – 83 (64.3%). The average age of the patients was (48 ± 8.7 years). By age, patients were divided into three groups: 1 group &#8...

Summary: Objective: To study the clinical manifestations of musculoskeletal complications (MSC) of acromegaly, to improve the early diagnosis of the disease.Materials and methods: 150 patients with acromegaly were examined who were observed at the RSSPMC of Endocrinology during the period from 2000 to 2020. The age of patients ranged from 19 to 76 years and averaged 43 ± 8.6 years. Of these, 65 (43.3%) were men and 85 (56.7%) women. Moreover, the du...

Tashkent Pediatric Medical Institute, department of endocrinology, Center of the Scientific and Clinical Study of Endocrinology, department of neuroendocrinoloy, Ministry of Health of the Republic of Uzbekistan. Republic of Uzbekistan, 100125, Tashkent, Mirzo Ulugbek str. 56Z. Yu. Khalimova, G.D. Narimova, Yu.M. Urmanova, G/O/ Alimukhamedova. Sh.M. SafarovaThe aim: To study the characteristic of associated diseases in risk groups o...

The purpose of the study: Is to study the frequency of thyroid diseases in adolescents (boys and girls) in 2 regions of the Republic of Uzbekistan.Material and methods.: We have been examined and surveyed in the framework of screening just for the period from January 1, 2021 to April 1, 2021 - 1023 boys and girls in the two regions of RUZ - 523 adolescents were examined in the Djizakh region and 500 adolescents in the Namangan region Aged from 11 to 15 y...

Aim: To study features of family inheritance in patients of non-functional pituitary adenomas (NFPA) in Uzbekistan.Materials and methods: We included 71 patients with NFPA, intrasellar localization (mean size >3 mm). Mean age was from 18 to 70 years old (range 44.5±3.85 years). Of 71 patients, 30 (42.3%) were men and 41 (57.7%) were women.All patients underwent clinical and biochemical evaluations including endocrine check...

Aim of the research: To study relationship between GH levels and acromegaly complications development in different therapy approaches.Patients and methods: We evaluated 50 patients with GH secreting adenomas referred to CCSSE from 1999 to 2004. Age of patients was from 19 to 63 years-old (mean age 40±19 years-old). Duration of the disease was from 1 to 23 years.Methods: Clinical and biochemical tests of neurological status; RI...

Aim of the research: To study clinical and epidemiologic features of acromegaly in the Republic of Uzbekistan.Patients and methods: We observed acromegalic patients registered from 2007 to 2009 who are dispensarized in the regions of the country. Of the 369 patients 143 were males (38.7%) and 226 females (61.3%). Mean age of the patients was 42.6 years-old. Duration of the disease varied from 1 to 31 years.Results: According to the...